mentzer index alpha thalassemia

Bei der α-Thalassämie sind zwei Gene namens HBA1 und HBA2 betroffen, die zur Manifestation der Krankheit führen. Alpha thalassemia is usually caused by a deletion of one or more of the alpha globin genes, leading to a decrease in alpha chain production and a relative excess of beta chains. Introduction Thalassemia, a disorder caused by the decrease or absence of one or more globin chains’ synthesis, is the most common genetic disorder in the world. Iron deficiency anemia Beta thalassemia major & intermedia Sickle thalassemia Hb H disease Red cell Fragmentation syndromeAnemia with high RDW 72. Alpha Thalassemia. The aim of our study was to evaluate the reliability of Mentzer index in the differentiation of iron deficiency anemia and Thalassemia trait. It is used to distinguish between two types of microcytic anemia: a value greater than 14 suggests iron deficiency anemia; a value less than 13 suggests thalassemia. There are nondeletional forms of alpha thalassemia, which may be more severe than deletional forms, but these are less common. Mentzer-Index. Thalassemia accounts for one third of all globin abnormalities; Gender: Males and females affected equally; Prevalence of Thalassemia. [Determination of the diagnostic value of erythrocyte discrimination indices (Mentzer and Srivastava) and of glycerol lysis time (GLT 50) in microcytosis]. Mentzer index, England and Fraser index, RDW index and Ehsani index each, showed highest specificity (99.66% each). Mentzer index could be used to predict the diagnosis of beta-thalassemia carrier. Alpha thalassemia is caused by alpha-globin gene deletion which results in reduced or absent production of alpha-globin chains. Mentzer Index (MI) MI > 13 eher Eisenmangel MI < 13 eher Beta-Thalassämie Wird im Labor ein Eisenmangel nach- gewiesen, kann eine Thalassämie erst nach erfolgter Korrektur des Eisen-mangels ausgeschlossen werden. Ein Mentzer-Index von weniger als 13 weist auf eine Diagnose der Beta-Thalassämie hin, während ein Wert von mehr als 13 auf einen Eisenmangel hindeutet. តាម Mentzer’s Index អាចអេាយយេីងគិតថា ជា thalassemia។ នេះជាអ្វីដែរត្រូវធ្វេីបន្ទាប់។ លទ្ធចេញមកគឺគាត់អាចមាន alpha thalassemia អាចជា minor form បេីតាម clinical and history ( … Mentzer index and RDW is a test that is widely used by clinicians to differentiating early screening of Thalassemia with iron deficiency anemia. Mentzer Index sensitivity (Sn) was 0.36 with specificity (Sp) at 0.81, positive predictive value (PPV) at 0.44 and negative predictive value (NPV) at 0.75. Mentzer index: (ments′ĕr) The mean corpuscular volume divided by the red blood cell count (in millions). Youden index which tells about the overall performance of a diagnostic test was highest for Kerman 1 index (65.4%). Similarly, no RBC index is good enough to diagnose thalassemia trait but Mentzer Index is best and most easily calculated among the broadly available formulae that can be used reliably in screening. Alpha thalassemia, which is characterized by genetic defects in the alpha-globin gene, is another known cause of mild microcytic anemia and has features similar to those of beta thalassemia. If the quotient of the mean corpuscular volume (MCV, in fL) divided by the red blood cell count (RBC, in Millions per microLiter) is less than 13, thalassemia is said to be more likely. Keywords: Mentzer Index, diagnostic value, thalassemia 1. Use this simple medical calculator ✅ to calculate mentzer index using mentzer index values. Alpha thalassemia trait Minor anemia 3 Hemoglobin H disease Mild to moderate anemia may lead normal life 4 Hydrops fetalis Fetal death usually occurs at birth Beta-thalassemia. Bildgebende Untersuchungen sind notwendig, um das Vorhandensein von Komplikationen, insbesondere … The individuals having thalassemia trait usually have asymptomatic course &have mild microcytic Mentzer index OR value was 2.4 (0.5 - 11.5, CI95%). Die Beta-Thalassämie major ist die schwerste Form von Beta-Thalassämie, gekennzeichnet durch eine völlige Abwesenheit von Beta-Globinketten im Hämoglobin. An index of less than 13.0 suggests that the patient has thalassemia trait, and an index of more than 13.0 is indicative of iron deficiency anemia. Bruccoleri F, Zepponi E, Balucanti F, et al. World wide: 1.7% (4.4 per 10,000 live births) Among at risk ethnicities: 5-30%; Ethnicity. the Mentzer index (MCV/red blood cell count) can help distinguish between iron deficiency and thalassemia. Dies führt zu einer schweren Anämie, die regelmäßige Bluttransfusionen erforderlich machen kann.… Beta-Thalassaemia major (Cooley-Anämie): Mehr zu Symptomen, Diagnose, Behandlung, Komplikationen, Ursachen und Prognose lesen. Mentzer Index sensitivity (Sn) was 0.36 with specificity (Sp) at 0.81, positive predictive value (PPV) at 0.44 and negative predictive value (NPV) at 0.75. Mentzer index calculator can give a fair idea of diagnosis on the basis of a simple complete blood count report. The Mentzer index is defined as mean corpuscular volume per red blood cell count. Online mentzer index calculator ✅. Mentzer index; Purpose: in differentiating iron deficiency anemia from beta thalassemia: The index is calculated from the results of a complete blood count. RDW index has highest positive predictive value (90.91%), while Green and King index has highest negative predictive value (98.87%). Sie nimmt bei Homozygoten einen sehr schweren… MENTZER INDEX(M.I)= <13 SEEN IN THALASSEMIA AND >13 IN … Im Vorfeld kann bereits durch den Mentzer-Index abgeschätzt werden, ob es sich eher um eine Eisenmangelanämie oder eine Beta-Thalassämie handelt. Mentzer index ( MCV in fL / RBC in millions per microliter ) if less than 13 is suggestive of thalassemia while more than 13 is seen in IDA. Alpha globin gene has 4 alleles and disease severity ranges from mild to severe depending on the number of deletions of the alleles. Beta thalassemias are due to mutations in the HBB gene on chromosome 11, also inherited in an autosomal, recessive fashion. The only 2 input parameters include Mean corpuscular volume (MCV) and Red Blood cell count (RBC count) which is available in CBC report.This App will give you a fair idea about the presumptive diagnosis. Differentialdiagnosen. Mentzer indeks(MI) dapat membantu membedakan defisiensi besi dengan thalassemia dimana pemeriksaan ini merupakan hasil perhitungan MCV/RBC.Bila hasil perhitungan >14 ( suggestive) indikasi anemia defisiensi besi, namun bila <12 (suggestive) indikasi thalassemia trait. Methods: This study was a prospective study done on 30 patients each of thalassemia trait and iron deficiency anemia (Total 60 patients). It is said to be helpful in differentiating iron deficiency anemia from beta thalassemia.. mentzer index(m.i)mentzer index(m.i) m.i =m.i = <13 seen in thalassemia<13 seen in thalassemia andand >13 in iron deficiency anemia>13 in iron … Die Differentialdiagnostik der Thalassämie umfasst andere Ursachen einer hypochromen mikrozytären Anämie, insb.. Eisenmangelanämie; Angeborene sideroblastische Anämie; Siehe auch: Diagnostik der Anämie AMBOSS erhebt für die hier aufgeführten Differentialdiagnosen keinen Anspruch auf Vollständigkeit. Use of the Mentzer index will assist in early diagnosis of iron deficiency in South African children. Alpha thalassemia major with hemoglobin Bart's usually results in fatal hydrops fetalis. Alpha thalassemia intermedia, or hemoglobin H disease, causes hemolytic anemia. It is estimated that 3 to 5% of the population in Indonesia is thalassemia carrier [2]. WHO reported that 5% of the world’s population is thalassemia carriers [1]. However, her Mentzer Index (the quotient of the corpuscular volume divided by the RBC count) of 14.4 is suggestive of iron-deficiency anemia. African descent (2% Incidence) Asian patients (Incidence common) Beta Thalassemia Mentzer index is such an index. Bei der α-Thalassämie handelt es sich um eine spezielle Form der Thalassämie. Alpha-Thalassämie: Die Thalassämie ist eine autosomal-rezessiv vererbte hämolytische Anämie. The Mentzer index, described in 1973 by William C. Mentzer, is the MCV divided by the RBC count. S Afr Med J 2015; 105:702. The percentage of correctly diagnosed cases was the highest for Red Cell Distribution Width Index (RDWI) (84.19%) followed by Mentzer Index (86.85%). gleda p baldini January 7, 2020 at 7:34 pm - Reply To Tapesh and Licia. Thalassämie und Kinderwunsch Es ist wichtig, dass Menschen mit Thalassämie informiert sind über die Vererbungsmöglichkeit und die damit verbundenen Risiken. Die Symptome der α-Thalassämie entstehen in der Folge einer verringerten Herstellung bestimmter Globinketten. • < 13 beta thalassemia more likely (thalassemia is a disorder of globin synthesis, normal amount of cells, but cells produced are smaller and more fragile, RBC Mentzer index of more than 13 was shown to be predictive of ID, meanwhile a value less than 13 favours thalassemia trait (17). Minor thalassemia :Alpha (Hb electrophoresis ) betadelta-beta Anemia of chronic disease (in late stagesspecially in renal disease )Anemia with normal RDW 71. High diagnostic accuracy in distinguishing Thalassemia with iron deficiency anemia was RDW index (88.14%), and followed by Mentzer index (86.85%). A Mentzer index of less than 13 suggests that the patient has the thalassemia trait, and an index of more than 13 suggests that the patient has iron deficiency. Keywords: anemia, mentzer index, RDW index, thalesemia. Objective: Thalassemia trait is commonly seen in Indian population especially in certain communities like Sindhis, Kachchis, Gujaratis& Bengalis. The most commonly used formulas are the following: Mentzer index (MI) = MCV/RBC; discriminant factor (DF) = MCV × (RDW/Hb × 100); Shine and Lal Index (S&L) = MCV × (MCH/100); Srivastava Index (SI) = MCH/RBC; RDW index (RDWI) = (MCV × RDW)/RBC. S Afr Med J 2015; 105:702. Mentzer’s Index • If CBC shows microcytic anemia, ratio of MCV/RBC can distinguish iron deficiency from thalassemia. 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